Origins of ... familial cancer: histopathological perspectives.

Origins of ... familial cancer: histopathological perspectives.

A Review of Internet-Centered Language Assessment: Origins, Challenges, and Perspectives

This article defines the origin of an internet-centered language assessment (ICLA), how ICLAs are different from the other traditional computer-oriented tests, and what uses and functions ICLAs have in different taxonomies of language testing. After a very short review of computer- oriented testing, ICLAs are defined and categorized in low-tech or high tech categories. Since low-tech tests are ...

New perspectives on anthropoid origins.

Adaptive shifts associated with human origins are brought to light as we examine the human fossil record and study our own genome and that of our closest ape relatives. However, the more ancient roots of many human characteristics are revealed through the study of a broader array of living anthropoids and the increasingly dense fossil record of the earliest anthropoid radiations. Genomic data a...

Genetic Perspectives on Human Origins

■ Abstract This is a review of genetic evidence about the ancient demography of the ancestors of our species and about the genesis of worldwide human diversity. The issue of whether or not a population size bottleneck occurred among our ancestors is under debate among geneticists as well as among anthropologists. The bottleneck, if it occurred, would confirm the Garden of Eden (GOE) model of th...

Old and new concepts in histopathological characterization of familial breast cancer.

BRCA1- and BRCA2-deficient cells display genomic instability due to impaired DNA repair and may subsequently be predisposed to malignant transformation. Cancers arising in BRCA1 gene mutation carriers differ substantially from sporadic breast cancers of age-matched controls in their histopathological appearance. BRCA1-related breast cancers have been morphologically associated with poorly diffe...